Dr. John Campbell
Definitive Evidence from Meta-Analysis and Trial Sequential Analysis https://www.ncbi.nlm.nih.gov/pmc/arti…
(Italy) Various studies, a association between severe vitamin D deficiency and bad COVID-19 outcomes. Vitamin D plays a crucial role in immune function and inflammation. Recent data suggest a protective role of vitamin D against bad outcomes.
Nutraceutical approach
Promote the immune response and reduce the inflammatory response Anti-inflammatory, antioxidant, and immunomodulatory properties of vitamin D. Immune optimisation and immune boosting Vitamin D maintains pulmonary barrier function. Determines the production of antimicrobial peptides. Enhances neutrophil activity. Shifts the adaptive immune response to a more T helper cell-2 type Anti-inflammatory effects of vitamin D. Reduces the production of pro-inflammatory cytokines, such as IL-6, IL-8, IL-9, IL-12, TNF alfa, IFN gamma. Increases production of anti-inflammatory cytokines, such as IL-4, IL-5, IL-10.
Patients with a low baseline vitamin D, more benefit. Reduce risk of asthma exacerbations. Prevents acute respiratory infections, and reducing their complications.
COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials https://www.ncbi.nlm.nih.gov/pmc/arti…
The rates of RT-CR positivity were significantly decreased in the intervention group as compared to the non-vitamin D groups.
Conclusively, COVID-19 patients supplemented with vitamin D, fewer rates of ICU admission, mortality events, and RT-PCR positivity.