Omicron is less severe and natural immunity works.
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Clinical outcomes among patients infected with Omicron (B.1.1.529) SARS-CoV-2 variant in southern California.
Omicron variant infection, reduced risk of hospitalization across age and comorbidity categories.
Risk of symptomatic hospitalization was markedly reduced among cases who had tested positive for SARS-CoV-2 infection ≥90 days prior.
Intrinsically less severe infection.
Less severe in vaccinated and unvaccinated.
Evidence for a reduction in severe outcomes among vaccinated cases with both Delta and Omicron variant infections in our study suggests substantial public health benefits from continued COVID-19 vaccination.