COVID Update – Different Variants Causing Different Symptoms And Paxlovid Rebound More Common

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Paxlovid is an anti-viral medication that can be used to treat outpatient COVID-19. It’s generic name is nirmatrelvir-ritonavir. For months there have been reports on rebound symptoms and rebound positive tests after recovering from COVID-19 for those who took Paxlovid.

COVID-19 Seems To Immediately Reoccur In Some After Treatment With Paxlovid – CDC Advisory Explained https://youtu.be/60RroTcpCTM

This was initially thought to happen in anywhere from 1-8% of individuals who took Paxlovid. A new study out though found closer to 20% had rebound symptoms and around 14% had rebound test positivity. Interestingly, 9% of those who didn’t take Paxlovid also had rebound test positivity and 7% had rebound symptoms. https://www.medrxiv.org/content/10.11…

Rebound Symptoms After Recovering from COVID-19 – Untreated, Paxlovid Treated, Vaccine Status https://www.youtube.com/watch?v=4Do3o…

Another study looking at over 1,500,000 people throughout the pandemic who had been infected with COVID-19 mapped out their symptoms as compared to the variant they were infected with. They found that early on in the pandemic with WT, Alpha, and Delta variants lack of smell and taste were far more predictive of having COVID-19. Now, upper respiratory symptoms such as congestion, sore throat, runny nose and viral syndrome symptoms like headache and fatigue are much more predictive. Interestingly, BA.2 actually has the largest symptom burden as compared to any of the previous variants. https://www.nature.com/articles/s4146…


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