Whiteboard Doctor
Omicron variant CH.1.1, also being called ORTHUS, has found its way into the news as a new COVID-19 variant to be aware of. Understand where this variant has spread, case counts, its origin, transmission, vaccine effectiveness, severity, how it compares to XBB.1.5, and more!!
It first started spreading in Southeast Asia in November, 2022. It is now the 5th most common variant in the United States and is in 66 countries, with the second most cases coming from the United Kingdom. With that being said, prevalence seems to be stable or decreasing in many places!
https://covid.cdc.gov/covid-data-trac…
https://cov-lineages.org/lineage.html…
CH.1.1 originated from BA.2.75 and has a number of additional mutations, including the L452R mutation found in BA.4, BA.5, and Delta. It is a cousin of XBB.1.5. It seems to be less infective than XBB.1.5 with a similar evasion from neutralization in those previously infected with BA.4, BA.5, or 3 doses of the mRNA vaccine. The Bivalent booster does seem to increase the neutralization of CH.1.1, although to a similar degree as XBB.1.5. Severity does not seem to be increased.
https://www.biorxiv.org/content/10.11…
Update – COVID-19 Omicron Variants (XBB.1.5 And CH.1.1), Case Counts, Hospitalizations, And Deaths https://www.youtube.com/watch?v=ba6-V…
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